• Green Synergy Engineering

Liquid Process Filters for High Purity Solutions in Healthcare

The manufacture of products for the healthcare industry utilizes a wide variety of molecules, extracts and formulations that must be safe, free of contamination, consistent and meet critical regulatory demands.


Graver Technologies’ range of products include prefilters, polishing filters, bioburden and sterilizing grade filters that meet these challenges and ensure reliable, high quality final products.


ACTIVE PHARMACEUTICAL INGREDIENTS

Chemically active substances used to treat, diagnose or prevent disease will require cost-effective clarification to remove particulate contamination used in the manufacturing process.


Recommended products:

  • Scepter crossflow membranes for high solids or aggressive conditions

  • PMC series pleated polypropylene for polishing carbon

  • Stratum C series melt blown for particle removal and DE/carbon trap


COSMETICS

Products that are derived from both natural and synthetic sources require optical clarity and in some instances, bioburden control and would include shampoos, deodorants, and toothpastes, in addition to skin moisturizers, cleansers, lipsticks, eye and face makeup and perfume.


Recommended products:

  • Stratum A melt blown series to provide effective optical clarity

  • PMA series pleated polypropylene media for particle removal and polishing for clarity

  • ZTEC B series Polyethersulfone membrane filters for bioburden control

  • QXL series pleated filters for capture of deformable particles common in natural extracts


DIAGNOSTICS

Reagents and chemicals that are intended to asses biologically derived samples to provide information in order to diagnose or treat diseases and demand a high degree of consistency from batch to batch.


Recommended products:

  • QMC series pleated polypropylene filters for membrane protection

  • GFC series pleaded microfiberglass for use as serum based prefilter

  • ZTEC B series pleated polyethersulfone membrane filter for bioburden control


OPHTHALMICS

These preparations may be sterile, liquid, semi-solid, or solids that may contain one or more active pharmaceutical ingredients intended for application to the eyes and require both particle and bioburden control.


Recommended products:

  • QMA series pleated polypropylene filters for particle removal and membrane prefilter

  • ZTEC B series pleated polyethersulfone filters for bioburden control

  • MBC/CMBF melt blown series for protection of downstream pleated filters


NUTRACEUTICALS

Products include nutrients, herbal products and dietary supplements that have a physiological benefit or offer protection against chronic disease.


Recommended products:

  • Scepter membrane to process high solids solutions

  • ZTEC B series pleated polyethersulfone membrane for microbial control at packaging

  • Stratum A series melt blown filter to produce visual clarity


USP WATER

The manufacture of pharmaceutical waters as defined by the United States Pharmacopoeia (USP) requires the removal or the reduction of the objectionable components to a tolerable level, followed by preserving the quality of the water thereafter.


Recommended products:

  • TefTEC and TefTEC V series pleated PTFE membrane for tank vents

  • Stratum A series melt blown to provide protection of membranes in high purity water systems

  • ZTEC P series polyethersulfone membrane filters to meet requirements for sterility


SMALL VOLUME PARENTERALS

Substances produced by means of cell harvesting, protein isolation and recovery or protein synthesis and are among the most regulated and validated products.


Recommended products:

  • ZTEC P series pleated polyethersulfone membrane for final sterile filtration of product

  • QMA series pleated polypropylene for optimal protection of the sterilizing grade membrane

  • Scepter crossflow membranes for post fermentation cell harvesting


LARGE VOLUME PARENTERALS

Sterile drug products that are typically emulsions, suspensions or reconstituted powders and are required to be essentially free from particles and microbiologically safe.


Recommended products:

  • ZTEC P series pleated polyethersulfone membrane for final sterile filtration of product

  • TefTEC series pleated PTFE membrane for tank vents

  • ZTEB B series pleated PES membrane as prefilter to sterilizing grade filter or high level particle control


Graver’s quality system has been certified to meet ISO 9001 standards. Final membrane filters are rinsed with ultrapure deionized water and integrity tested prior to release. Complete traceability is ensured by the engraving of lot numbers on all filters, plus pore size identification on membrane fiters to assist customer installation accuracy. Membrane filters are flushed with ultrapure water, tested and packaged in an ISO Class 7 cleanroom.


Whether producing utility air, diagnostics or antibiotics, Graver Technologies has a market solution. Contact us to find out more about our products and services.

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